Participating Partners: DC
Douglas Connect (DC) will provide access to computational tools, supporting the users in data extraction, and analysis.
DC will develop user guidance and offer help desk services for accessing the knowledge base and data mining. In this respect, DC is undertaking a major effort to simplify and modernise data access to scientific data sources, currently focusing on the field of toxicology, including nanotoxicology. DC are creating applications to make data accessible online via the internet in real time harmonising and integrating data resources (e.g., as implemented within the current OpenRiskNet interoperability layer) and supporting diverse user applications from search through data analysis and modelling through read-across and other approaches.
DC’s TA offer will include provision of Access to the following DC resources (and associated technologies in data management and analysis):
- DC Summit Knowledge Integrating Application – www.summit.enanomapper.net. A web-based knowledge integrating application created as an evidence-based collaborative support tool for nano-safety related case studies, with potential for extension to other areas.
- DC Data Explorer Application – www.data.douglasconnect.com. DC is undertaking a major effort to simplify and modernise data access to scientific data sources, currently focusing on the field of toxicology. Three of the most popular toxicologic data sources are already publicly available for consumption: The EPA’s in vitro ToxCast/Tox21 database, the EPA’s in vivo ToxRefDB database and the NIBIOHN’s toxicogenomics Open TG-Gates database.
- DC Integrated Testing Strategy Application – www.its.douglasconnect.com. DC ITS SkinSens provides an open implementation of the integrated testing strategy (ITS) that assesses skin sensitisation potency based on the previously described approach developed at Procter & Gamble. The DC-ITS implementation combines information from three validated alternative assays (DPRA, KeratinoSens and h-CLAT) with in silico predictions for bioavailability using open cheminformatics tools.
- DC Risk Assessment Application – www.risk.douglasconnect.com. The service uses an OpenTox approach to collect and organize existing toxicology data and modeling tools from different sources and presents them to the risk assessor supporting their risk assessment. An easy to use interface provides seamless data gathering and recording of argumentations and conclusions for each step when performing a risk assessment.
The computation tools offered by DC for TA fall under four categories:
- Ontology services
- Data Processing and Analysis services
- Predictive nanotoxicology tools
- Data visualisation and Risk Assessment tools.
DC offers support to Users in the design of their experiments to be directly compatible with the processing tools, or, for Users that already have datasets, DC will work with the Users to format the existing data utilising the data processing tools to enable analysis, predictive nanotoxicology and/or visualisation of the data sets. Full computational time and power, technical expertise, bioinformatics support and analysis and paper writing support are included in the TA package offered by DC to fully support Users’ nanoinformatics needs and ensure that the tools are made available / accessible for virtual access also with full User online support.