A crucial step that should be performed after the development of a predictive model, is to disseminate the model’s results and facilitate its use by all interested stakeholders in real-life applications. It is also important to simplify the different technical aspects of the model and present its important features and results through a user-friendly environment, especially designed for non-informatics experts. The Enalos Cloud platform, developed by NovaMechanics Ltd, is an online, freely available toxicity and drug discovery platform, that hosts predictive models released as web services, which aim to address the need to reduce the amount of time and cost spent on experimental testing during the drug discovery and the risk assessment procedures for small molecules and NMs. Several predictive models, based on open source and in house algorithms and software, are already available within the Enalos Cloud platform, including models for NMs toxicity, biological activity and properties evaluation.
NanoXtract is a unique online tool for the calculation of image descriptors based on Transmission Electron Microscopy (TEM) images of nanomaterials (NMs) was developed and made available through the Enalos Nanoinformatics platform. The tool can generate a set of 18 image descriptors that greatly enhance and enrich the information extracted from images (currently only size, size-distribution and qualitative information on shape and morphology), and which can be explored using quantitative structure activity relationship (QSAR) models to identify those descriptors most predictive of NM behaviour and /or biological effects. This tool fulfils the unmet need for the generation of larger sets of nano-specific descriptors with minimal experimental data requirements. Within a simple and user-friendly interface, the user can upload a NM TEM image and with just a few clicks to select the core and coating descriptors, obtain a significant set of NM image descriptors.
- Provided by: NovaMechanics Ltd.
- Type: Image analysis
- Applicability domain: TEM microscopy images of nanoparticles
- Topic: Data analysis
- Contact: Antreas Afantitis
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