The updated NanoCommons deliverable “D4.4 – First version of data warehouse and collaborative knowledge infrastructure” is now available to view online. The report is available under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). Deliverable 4.4 is part of Task 4.2 that deals with the development of the NanoCommons Knowledge Base and Warehouse that aims to collect raw and processed data generated by different projects and to provide support and processes for preparing datasets for upload to the NanoCommons data warehouse or other specialized databases linked into the infrastructure, as well as templates for data collection (linked to the online notebooks). Additionally, repositories for protocol description directly linked to the relevant datasets are provided in order for complete coverage of the experimental procedure and results to be included into the system. The work in this task is based on the concepts and aligned with developments from previous and ongoing projects (e.g. eNanoMapper, NANoREG, NanoMILE, NanoFASE, SmartNanoTox, ACEnano, etc.) and is extended in order to cover additional areas of nano safety research. It considers requirements for regulatory reporting and Adverse Outcome Pathway (AOP) development, as well as the support of ontology development and semantic annotation. In this way, the warehouse facilitates data transfer to and from other databases as part of a federated data ecosystem.