Omics Data Analysis

Omics Data AnalysisOverview The NanoCommons Knowledge Base is based on the BioXM TM Knowledge Management Environment, a software developed over the last 15 years by Biomax Informatics AG and applied in multiple collaborative research projects and commercial environments. Within NanoCommons the following services are offered: Omics data analysis tools The following methods are currently available to…

NanoCommons Knowedge Base

NanoCommons Knowledge BaseOverview The NanoCommons Knowledge Base is based on the BioXM TM Knowledge Management Environment, a software developed over the last 15 years by Biomax Informatics AG and applied in multiple collaborative research projects and commercial environments. Within NanoCommons the following services are offered: Data management ensuring FAIR principles Particles ordering management Collaborative projects as…

Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor

Abstract Receptor tyrosine kinases (RTKs) typically contain multiple autophosphorylation sites in their cytoplasmic domains. Once activated, these autophosphorylation sites can recruit downstream signaling proteins containing Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains, which recognize phosphotyrosine-containing short linear motifs (SLiMs). These domains and SLiMs have polyspecific or promiscuous binding activities. Thus, multiple signaling proteins may…

OpenRiskNet / NanoCommons ontology meeting

Workshop, Hackathon (co-organised by OpenRiskNet and NanoCommons) 13 – 14 Dec 2018 / Brussels, BE Activity details The goal of this meeting is to get a picture of the ongoing ontology activities in the toxicology area, harmonise these efforts and the developed ontologies therein, and extend the existing toxicology ontology to support OpenRiskNet and NanoCommons…

Accelerate your research with CORBEL’s 2nd Open Call for biomedical research projects

The CORBEL* Open Call invites researchers from academia and industry to apply to access a wide range of high-end technologies and services from more than 20 facilities from 10 different research infrastructures across Europe. These include state-of-the-art offers from the fields of advanced imaging, biobanking, clinical and translational research, curated databases, marine model organisms, mouse…

A safe-by-design tool for functionalised nanomaterials through the Enalos Nanoinformatics Cloud platform

NanoCommons supported paper: A safe-by-design tool for functionalised nanomaterials through the Enalos Nanoinformatics Cloud platform Abstract Multi-walled carbon nanotubes are currently used in numerous industrial applications and products, therefore fast and accurate evaluation of their biological and toxicological effects is of utmost importance. Computational methods and techniques, previously applied in the area of cheminformatics for…

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

Abstract Clinically used RAF inhibitors are ineffective in RAS mutant tumors because they enhance homo- and heterodimerization of RAF kinases, leading to paradoxical activation of ERK signaling. Overcoming enhanced RAF dimerization and the resulting resistance is a challenge for drug design. Combining multiple inhibitors could be more effective, but it is unclear how the best combinations can…