Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Abstract Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000…

D10.3 – Initial version of NanoCommons Sustainability Plan

The NanoCommons deliverable “D10.3 – Initial version of NanoCommons Sustainability Plan” is now available to view online. The report is available under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). During the first year of the project a strategy was developed for ensuring sustainability of the NanoCommons research infrastructure and including the tools and services…

D10.2 – Interactions Needs and Goals of Nano Safety Projects and Programs

The updated NanoCommons deliverable “D10.2 – Interactions Needs and Goals of Nano Safety Projects and Programs” is now available to view online. The report is available under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). The Horizon 2020 (H2020) project NanoCommons is establishing a long-term infrastructure to benefit nanotechnology and nanosafety research. This means that…

D6.1 – A workflow and checklist for experimental design and informatics workflow for risk assessment for use in WP9

The NanoCommons deliverable “D6.1 – A workflow and checklist for experimental design and informatics workflow for risk assessment for use in WP9” is now available to view online. The report is available under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). The development of safe and effective nanomaterials (NMs) is highly important for both industry…

D5.5 – A workflow and checklist of key information needed from modelling tool owners to facilitate integration into KB

The NanoCommons deliverable “D5.5 – A workflow and checklist of key information needed from modelling tool owners to facilitate integration into KB” is now available to view online. The report is available under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). This deliverable is part of Work Package 5 (WP5), which aims to integrate state-of-the-art…

D5.4 – First predictive nanoQSAR models integrated into NanoCommons KnowledgeBase

The NanoCommons deliverable “D5.4 – First predictive nanoQSAR models integrated into NanoCommons KnowledgeBase” is now available to view online. The report is available under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). This Deliverable report (D5.4) presents the services that have been developed and are available through the NanoCommons infrastructure for generating and validating nano-specific…

D5.3. – First raw data processing and knowledge extraction tools integrated into KB and first theoretical descriptor calculation services available

The NanoCommons deliverable “D5.3. – First raw data processing and knowledge extraction tools integrated into KB and first theoretical descriptor calculation services available” is now available to view online. The report is available under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). This Deliverable (D5.3) focuses on (i) tools developed for processing of raw data…

D5.2 – First big data (omics) analysis and mining tools integrated into KnowledgeBase

The NanoCommons deliverable “D5.2 – First big data (omics) analysis and mining tools integrated into KnowledgeBase” is now available to view online. The report is available under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). The current deliverable is part of Work Package 5 (WP5) Joint Research Activity 3 (JRA3) – Analysis and Modelling Tools,…

D5.1 – Initial Knowledge Infrastructure Functionalities and Services Implemented

The updated NanoCommons deliverable D5.1 – Initial Knowledge Infrastructure Functionalities and Services Implemented is now available to view online. The report is available under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). The scope of Work Package 5 (WP5) is the integration of the state-of-the-art tools for data management, mining, handling, analysis and predictive modelling…